反应详情

温度

0 °C

Phosphorus oxychloride (1.83 ml) was added dropwise to dimethylformamide (16 ml) under ice-cooling, and the mixture was stirred at 0° C. for 20 min. 6-Chloro-5-(trifluoromethyl)-1H-indole (3.24 g) dissolved in dimethylformamide (10 ml) was added to the reaction mixture, and the mixture was stirred at 0° C. for 3 hr. Water was added to the reaction mixture, and the mixture was stirred at room temperature for 3 hr, and the mixture was alkalified with a 1N aqueous sodium hydroxide solution. The precipitated solid was collected by filtration, washed with water and dried to give 6-chloro-5-(trifluoromethyl)indole-3-carbaldehyde (3.25 g, yield 89%).

1. temperaturecooling
2. additionwas added to the reaction mixture
3. stirringthe mixture was stirred at 0° C. for 3 hr
4. stirringthe mixture was stirred at room temperature for 3 hr
5. filtrationThe precipitated solid was collected by filtration
6. washwashed with water
7. customdried