反应详情

Nitromethane (20 ml) and ammonium acetate (1.6 g) were added to 6-chloro-5-(trifluoromethyl)indole-3-carbaldehyde (3.25 g) and the mixture was heated under reflux for 1 hr. The reaction mixture was allowed to cool, and the precipitated solid was collected by filtration, washed with methanol-water (1:1) and dried to give a brown solid. This solid was washed in a suspension state with diethyl ether, collected by filtration and dried to give 6-chloro-3-[(E)-2-nitrovinyl]-5-(trifluoromethyl)-1H-indole (1.86 g, yield 49%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1 hr
3. temperatureto cool
4. filtrationthe precipitated solid was collected by filtration
5. washwashed with methanol-water (1:1)
6. customdried
7. customto give a brown solid
8. washThis solid was washed in a suspension state with diethyl ether
9. filtrationcollected by filtration
10. customdried