Triethylamine → HCID 10014060, compound

HRID 1670750Notes

Reaction equation

HRID 1670750 reaction equation
Cl.[Cl:2][CH2:3][C:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][CH2:6][N:5]=1.[CH2:17]([N:19](CC)[CH2:20]C)C>>[CH3:17][N:19]([CH3:20])[CH2:3][CH:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][CH2:6][NH:5]1.[ClH:2].[CH3:4][NH:5][CH3:6]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 135599827HCID 135599827, compound

Product 2

HCID 10473Dimethylamine, hydrochlorideHCID 10014060HCID 10014060, compoundYield 72%

Procedure

By a similar operation as in Starting Material Synthetic Example 21 and adding triethylamine (1.28 ml), dimethyl(2,3,4,9-tetrahydro-1H-β-carboline-1-ylmethyl)amine (305 mg, yield 72%) was obtained from dimethylamine hydrochloride (751 mg) and 1-chloromethyl-4,9-dihydro-3H-β-carboline hydrochloride (synthesized according to the method described in J. Med. Chem., 34, 8, 1991, 2624-2633, 470 mg).

Sources & evidence

ORD record
ord-7c13e3fc8d124b678ebc7058ef1d2e15
Source dataset
uspto-grants-2011_08
Patent number
US07994196B2

Reaction notes

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