反应详情

Stir a mixture of potassium phthalimide (1.85 g, 10 mmol), 2-bromomethyl-1,3-dichloro-5-methoxy-benzene (2.68 g, 10 mmol) and DMF (20 mL) at 50° C. for 12 hours. Cool the reaction and dilute with ethyl acetate (60 mL) and wash with water three times and brine one time. After drying the organic layer over sodium sulfate, filter and concentrate under vacuum. Purify the residue by silica gel chromatography with 1:3 ethyl acetate/hexane to afford 2.74 g (82%) of the title compound. MS (m/z): 336 (M+H)+.

1. temperatureCool
2. customthe reaction
3. washwash with water three times and brine one time
4. dry with materialAfter drying the organic layer over sodium sulfate
5. filtrationfilter
6. concentrationconcentrate under vacuum
7. customPurify the residue by silica gel chromatography with 1:3 ethyl acetate/hexane