Ethyl 4-hydroxyphenylacetate → HCID 14022788, compound

HRID 1670817Notes

Reaction equation

HRID 1670817 reaction equation
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[CH3:2]>[Rh].C(O)C>[CH2:1]([O:3][C:4](=[O:13])[CH2:5][CH:6]1[CH2:7][CH2:8][CH:9]([OH:12])[CH2:10][CH2:11]1)[CH3:2]

Participants

4

Reactant 1

HCID 28310Ethyl 4-hydroxyphenylacetate

Product 1

HCID 14022788HCID 14022788, compoundYield 99.7%

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 702EthanolSolvent

Procedure

Stir a mixture of (4-hydroxy-phenyl)-acetic acid ethyl ester (78.86 g), Rhodium on aluminum oxide (40%, 31.87 g) and ethanol (1 L) on a hydrogenation parr shaker at 60 psi, 60° C. for 18 hours. Remove the reaction from parr shaker. Filter the mixture through celite and concentrate the to afford 81.25 g (99%) of the title compound.

Workup

  1. customRemove
  2. customthe reaction from parr shaker
  3. filtrationFilter the mixture through celite and
  4. concentrationconcentrate the

Sources & evidence

ORD record
ord-db844cb313b944488c2dbe08b6d5c8aa
Source dataset
uspto-grants-2011_08
Patent number
US07994176B2

Reaction notes

Loading…