反应详情

Treat a solution of 3-(4-methoxycyclohexyl)-pyrrolidin-2-one (0.0.71 g, 3.6 mmol) in DMF (20 mL) with a sodium hydride (0.0.29 mL, 7.2 mmol) and stir at room temperature for 10 minutes under N2. Treat the reaction with 5-Bromo-2-bromomethyl-1,3-dichloro-benzene (1.36 g, 4.3 mmol). Stir the mixture for 14 hours. Quench the reaction with water and extract with ethyl acetate. Dry the organic layer (Na2SO4), remove the solvent in vacuo to afford crude product, and purify with 25% ethyl acetate in hexanes to afford 0.45 g of the title compound.

1. additionTreat
2. stirringStir the mixture for 14 hours
3. customQuench
4. customthe reaction with water
5. extractionextract with ethyl acetate
6. dry with materialDry the organic layer (Na2SO4)
7. customremove the solvent in vacuo
8. customto afford crude product
9. custompurify with 25% ethyl acetate in hexanes