Hydrochloric Acid → HCID 67018180, compound

HRID 1671680Notes

Reaction equation

HRID 1671680 reaction equation
C(OC([N:8]1[CH2:11][CH2:10][C@H:9]1[CH2:12][NH:13][C:14]([C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[O:24][CH:23]=[CH:22][C:21]=12)=[O:15])=O)(C)(C)C.[ClH:25]>CC(O)C>[ClH:25].[NH:8]1[CH2:11][CH2:10][C@H:9]1[CH2:12][NH:13][C:14]([C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[O:24][CH:23]=[CH:22][C:21]=12)=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67018206HCID 67018206, compound

Product 1

HCID 67018180HCID 67018180, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

To a solution of (2S)-{[(benzofuran-4-carbonyl)-amino]-methyl}-azetidine-1-carboxylic acid tert-butyl ester (170 mg) in 2-propanol (4 mL) was added 5-6M HCl in 2-propanol (2 mL). The resulting reaction mixture was stirred at RT under nitrogen for 20 h and concentrated in vacuo to yield 120 mg (85%) of the title compound as an oil.

Workup

  1. customThe resulting reaction mixture
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6c5109bc24e144f1b6d34d3be12f53c3
Source dataset
uspto-grants-2011_08
Patent number
US07994336B2

Reaction notes

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