Hydrochloric Acid → HCID 178484818, compound

HRID 1671755Notes

Reaction equation

HRID 1671755 reaction equation
CC(O[C:6]([N:8](C)[C@@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][CH2:10]1)=O)(C)C.Cl>O1CCOCC1>[CH3:6][NH:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178501225HCID 178501225, compound

Product 1

HCID 178484818HCID 178484818, compoundYield 47.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of methyl cis-4-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]cyclohexanecarboxylate (˜10 g, crude product from above) and 1M HCl in dioxane (20 mL) was heated to 50° C. and allowed to stir overnight. The mixture was concentrated to give the 3 g of crude product. MS (ES+): m/e 172.1 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-a6b20da3e5864e3c8382e18b299dd11a
Source dataset
uspto-grants-2011_08
Patent number
US07994317B2

Reaction notes

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