反应详情

To a solution of cis-4-{[4-chloro-6-(methylamino)-2-pyrimidinyl]amino}-N-{[2-(trifluoromethyl)phenyl]methyl}cyclohexanecarboxamide (50.0 mg, 0.11 mmol) and benzylamine (59.0 mg, 0.55 mmol) in 2-propanol (3 mL) was added one drop of concentrated HCl. The mixture was irradiated in the microwave for 3 hours at 170° C., at which time LCMS indicated the formation of the desired product. The crude reaction mixture was filtered and purified directly by preparative HPLC (gradient; 30-80% CH3CN:H2O (0.1% TFA)), to afford the title compound (30 mg, 0.58 mmol, 52%). MS (ES+) m/e 513 [M+H]+.

1. customThe mixture was irradiated in the microwave for 3 hours at 170° C., at which time LCMS