2-(Methylamino)ethanol → HCID 85830820, compound

HRID 1672107Notes

Reaction equation

HRID 1672107 reaction equation
[CH3:1][O-:2].[Na+].[C:4]([O:23]C)(=O)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21].[CH3:25][NH:26][CH2:27][CH2:28][OH:29]>>[C:1]([O:29][CH2:28][CH2:27][N:26]([C:4](=[O:23])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH3:25])(=[O:2])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH3:4]

Participants

4

Reactant 3

HCID 80162-(Methylamino)ethanolHCID 8201Methyl StearateHCID 10942334Sodium Methoxide

Product 1

HCID 85830820HCID 85830820, compound

Procedure

50 Parts by weight of 28% sodium methylate is added to 100 parts by weight of methyl stearate and 26 parts by weight of N-methylethanolamine, and an amidation reaction is allowed to proceed at 90° C. while removing methanol. Subsequently, sodium methylate is decomposed by using 66 parts by weight of 35% hydrochloric acid and after dehydration, sodium chloride is removed by filtration. Thereafter, 33 parts by weight of stearic acid is added to 100 parts by weight of the solid material, and an esterification reaction is performed at 170° C. while effecting dehydration, whereby N-stearoyl-N-methylamino-ethyl stearate is obtained.

Workup

  1. customan amidation reaction
  2. customto proceed at 90° C.
  3. customwhile removing methanol
  4. customafter dehydration, sodium chloride is removed by filtration
  5. additionThereafter, 33 parts by weight of stearic acid is added to 100 parts by weight of the solid material
  6. customan esterification reaction
  7. customis performed at 170° C.

Sources & evidence

ORD record
ord-fc7ea29e432e43e28b6e7dbb34d6e11c
Source dataset
uspto-grants-2011_08
Patent number
US07998647B2

Reaction notes

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