反应详情

温度

40 °C

6 ml phosphorus oxychloride are added dropwise to 12.1 g 3,4-dihydro-4-oxo-6-(1,4-dioxa-spiro[4,5]decan-8-yl-oxy)-7-methoxy-quinazoline in 120 ml acetonitrile and the mixture is heated to an internal temperature of 40° C. Then 9.3 ml triethylamine are added dropwise and the reaction mixture is refluxed for 3 hours. The mixture is cooled to ambient temperature and left to stand overnight. The solution of the product is reacted further without any purification (see Example III).

1. temperaturethe reaction mixture is refluxed for 3 hours
2. temperatureThe mixture is cooled to ambient temperature
3. waitleft
4. customThe solution of the product is reacted further without any purification (see Example III)