2-Bromoaniline → HCID 60046925, compound

HRID 1672336Notes

Reaction equation

HRID 1672336 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:10]=2)[N:5]=[CH:4][C:3]=1[N+:18]([O-:20])=[O:19].[Br:21][C:22]1[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=1[NH2:24]>C(O)(=O)C>[Br:21][C:22]1[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=1[NH:24][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:10]=2)[N:5]=[CH:4][C:3]=1[N+:18]([O-:20])=[O:19]

Participants

4

Reactant 2

HCID 119922-BromoanilineHCID 60046927HCID 60046927, compound

Product 1

HCID 60046925HCID 60046925, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound is prepared in analogy to Example 19d, starting from 0.5 g (1.756 mmol) 4-chloro-3-nitro-6-phenyl-quinoline (Example 53d) and 0.339 g (1.932 mmol) 2-bromoaniline in 3 ml acetic acid. mp: 198-204° C.; MS: 420 (M++1); HPLC: tret=12.17 min (Grad 1).

Workup

  1. customtret=12.17 min (Grad 1)

Sources & evidence

ORD record
ord-89dfaf65b0cd431989bbc98e79103f00
Source dataset
uspto-grants-2011_08
Patent number
US07998972B2

Reaction notes

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