Sodium Carbonate → HCID 178510789, compound

HRID 1672340Notes

Reaction equation

HRID 1672340 reaction equation
[C:1]1([C:7]2[CH:16]=[CH:15][C:14]3[N:13]=[CH:12][C:11]4[N:17]=[CH:18][N:19]([C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=5[CH2:26][C:27]#[N:28])[C:10]=4[C:9]=3[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:30][OH:31].C(=O)([O-])[O-].[Na+].[Na+]>CN(C=O)C.O>[OH:31][NH:30][C:27](=[NH:28])[CH2:26][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[N:19]1[C:10]2[C:9]3[CH:8]=[C:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[CH:16]=[CH:15][C:14]=3[N:13]=[CH:12][C:11]=2[N:17]=[CH:18]1

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 10428607HCID 10428607, compound

Product 1

HCID 178510789HCID 178510789, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

The title compound is prepared in analogy to Example 67 starting from 300 mg (0.832 mmol) of [2-(8-phenyl-imidazo[4,5-c]quinolin-1-yl)phenyl]-acetonitrile (Example 64), 346 mg (0.499 mmol) hydroxylamine hydrochloride in 7 ml DMF, and 465 mg sodium carbonate in 2.5 ml water. The compound is isolated as colorless powder. mp: 253-254° C.; MS: 394 (M+1); HPLC: tret=6.57 min (Grad 1).

Workup

  1. customThe compound is isolated as colorless powder
  2. customtret=6.57 min (Grad 1)

Sources & evidence

ORD record
ord-b9271853ce404d4b9eff5624139a9408
Source dataset
uspto-grants-2011_08
Patent number
US07998972B2

Reaction notes

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