Tert-butyl 7-(2-chlorophenyl)-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate → 7-(2-Chlorophenyl)-1,7-diazaspiro[4.4]nonan-6-one

HRID 1672377Notes

Reaction equation

HRID 1672377 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:23][CH2:22][C:10]2([N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12][CH2:11]2)[C:9]1=[O:24]>Cl.O1CCOCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:23][CH2:22][C:10]2([NH:14][CH2:13][CH2:12][CH2:11]2)[C:9]1=[O:24]

Participants

4

Reactant 1

HCID 58948328Tert-butyl 7-(2-chlorophenyl)-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate

Product 1

HCID 589483317-(2-Chlorophenyl)-1,7-diazaspiro[4.4]nonan-6-one

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 7-(2-chlorophenyl)-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate was dissolved in a 4.0 M solution of HCl in 1,4-dioxane, and the resulting mixture was stirred for 2 h at RT. The volatiles were removed in vacuo to afford the desired product, which was used in the next step without further purification. LC-MS: 251.0 (M+1H)+.

Workup

  1. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-5406c69575c84195a4ecccde24d5964a
Source dataset
uspto-grants-2011_08
Patent number
US07998959B2

Reaction notes

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