Trifluoroacetic acid → HCID 178511657, compound

HRID 1672495Notes

Reaction equation

HRID 1672495 reaction equation
[CH2:1]([NH:8][C:9]([C:11]1[CH:20]=[C:19]2[C:14]([CH:15]=[N:16][C:17]([NH:21][C@H:22]3[CH2:27][CH2:26][C@H:25]([NH:28]C(=O)OC(C)(C)C)[CH2:24][CH2:23]3)=[N:18]2)=[CH:13][CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:28][C@H:25]1[CH2:24][CH2:23][C@H:22]([NH:21][C:17]2[N:16]=[CH:15][C:14]3[C:19](=[CH:20][C:11]([C:9]([NH:8][CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[O:10])=[CH:12][CH:13]=3)[N:18]=2)[CH2:27][CH2:26]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178454022HCID 178454022, compound

Product 1

HCID 178511657HCID 178511657, compoundYield 100.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The tert-butyl [trans-4-({7-[(benzylamino)carbonyl]quinazolin-2-yl}amino)cyclohexyl]carbamate (780.0 mg, 2.0 mmol) was treated with TFA (2.3 g, 20.0 mmol) in DCM (15 ml) at 50° C. for 2 hours. Removal of solvent and TFA gave 758.0 mg of product without further purification. MS m/z, (APCI); 378.5 ([M+H]+).

Workup

  1. customRemoval of solvent and TFA

Sources & evidence

ORD record
ord-1b6578e4556242aebd4fa9cadcf3dfba
Source dataset
uspto-grants-2011_08
Patent number
US07998978B2

Reaction notes

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