Trifluoroacetic acid → Trifluoroacetate

HRID 1672515Notes

Reaction equation

HRID 1672515 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10](=[O:15])[NH:11][CH2:12][CH2:13][F:14])(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[NH2:7][CH2:8][CH2:9][C:10]([NH:11][CH2:12][CH2:13][F:14])=[O:15].[F:17][C:18]([F:23])([F:22])[C:19]([O-:21])=[O:20]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86634504HCID 86634504, compound

Product 2

HCID 84468TrifluoroacetateHCID 86634505HCID 86634505, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of [2-(2-Fluoro-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (0.353 g, 1.51 mmol) in dichloromethane (10 ml) was treated with trifluoroacetic acid (1 ml) and the reaction stirred at ambient temperature for 4 hours. The solvent was evaporated to dryness to yield the titled product as a trifluoroacetate salt.

Workup

  1. customThe solvent was evaporated to dryness

Sources & evidence

ORD record
ord-ab087be44230416e9fbd43799d91d375
Source dataset
uspto-grants-2011_08
Patent number
US07998990B2

Reaction notes

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