反应详情

To a solution of 1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one (447 mg, 2.2 mmol) in 22 mL dry THF, add 1.76 mL of 2M LDA (1.2 eq.) in THF dropwise at −78° C. Then, add 1.24 g of trifluoro-methanesulfonic acid 3,5-dichloro-4-methanesulfonyloxymethyl-phenyl ester (1.4 eq) at −78° C. Allow the resulting solution to stand at room temp for overnight. Quench the mixture with saturated aqueous NH4Cl and extract with CH2Cl2. Wash the organic layer with water, then brine, and dry over Na2SO4, filter and concentrate. Purify the crude material by chromatography to afford the title compound: mass spectrum (m/z): 376 (M+1).

1. customQuench the mixture with saturated aqueous NH4Cl
2. extractionextract with CH2Cl2
3. washWash the organic layer with water
4. dry with materialbrine, and dry over Na2SO4
5. filtrationfilter
6. concentrationconcentrate
7. customPurify the crude material by chromatography