Triethylamine → HCID 67351688, compound

HRID 1672767Notes

Reaction equation

HRID 1672767 reaction equation
Cl.Cl.[CH2:3]([NH:5][C:6]1[N:7]=[CH:8][C:9]2[C:18](=[O:19])[N:17]([CH2:20][CH:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[CH2:16][C@H:15]3[N:11]([CH2:12][CH2:13][CH2:14]3)[C:10]=2[N:27]=1)[CH3:4].Cl[C:29]1[CH:37]=[CH:36][C:32]([C:33]([NH2:35])=[O:34])=[CH:31][N:30]=1.C(N(CC)CC)C>C(O)C>[CH2:3]([NH:5][C:6]1[N:7]=[CH:8][C:9]2[C:18](=[O:19])[N:17]([CH2:20][CH:21]3[CH2:22][CH2:23][N:24]([C:29]4[CH:37]=[CH:36][C:32]([C:33]([NH2:35])=[O:34])=[CH:31][N:30]=4)[CH2:25][CH2:26]3)[CH2:16][C@H:15]3[N:11]([CH2:12][CH2:13][CH2:14]3)[C:10]=2[N:27]=1)[CH3:4]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 804566-ChloronicotinamideHCID 67352345HCID 67352345, compound

Product 1

HCID 67351688HCID 67351688, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
140 °C

Procedure

Compound 24 (50.9 mg, 0.122 mmol) obtained in Example 24, and 6-chloronicotinamide (38.2 mg, 0.244 mmol) were dissolved in ethanol (1.0 mL), and the mixture was stirred at 140° C. for 2 hours under microwave (CEM; Discover, 300 watts) irradiation after adding triethylamine (169 μL, 1.22 mmol). Thereafter, ethanol (1.0 mL) was added to the reaction mixture, and the mixture was stirred at room temperature for 1 hour. The precipitated solid was filtered off and dried to give the title compound (Compound 28) (34.7 mg, 62%).

Workup

  1. stirringthe mixture was stirred at room temperature for 1 hour
  2. filtrationThe precipitated solid was filtered off
  3. customdried

Sources & evidence

ORD record
ord-c871c56203b34c02bac50fd32b1ef85b
Source dataset
uspto-grants-2011_08
Patent number
US07998954B2

Reaction notes

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