Triethylamine → HCID 86640019, compound

HRID 1673057Notes

Reaction equation

HRID 1673057 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH:13]=[C:12]([C:14]#[N:15])[N:11]=[CH:10]1.C[NH:19]O.Cl.CCN(CC)CC>CCO>[F:17][C:2]([F:16])([F:1])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH:13]=[C:12]([C:14](=[NH:19])[NH2:15])[N:11]=[CH:10]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 77906N-methylhydroxylamine hydrochlorideHCID 86640018HCID 86640018, compound

Product 1

HCID 86640019HCID 86640019, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1-(3′-methylsulfonyl)biphenyl-4-yl)-2-(2-(trifluoromethyl)phenyl-1H-imidazole-4-carbonitrile (374 mg, 0.8 mmol), MeNHOH.HCl (167 mg, 2 mmol), Et3N (0.5 mL), and dry EtOH in a sealed vial was stirred at 80° C. for 2 h, the volatiles were removed in vacuo to give N-hydroxy-N-methyl-1-(3′-methylsulfonyl)biphenyl-4-yl)-2-(2-(trifluoromethyl)phenyl-1H-imidazole-4-carboximidamide as a white solid, which was used in next reaction without further purification.

Workup

  1. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-ee39c82bb3954e6c991b15be99241bf5
Source dataset
uspto-grants-2011_08
Patent number
US07998995B2

Reaction notes

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