HCID 59715735, compound → HCID 59715643, compound

HRID 1673093Notes

Reaction equation

HRID 1673093 reaction equation
[CH2:1]([C:5]1[CH:23]=[CH:22][C:8]([CH2:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:20]#[CH:21])[CH:18]=3)[CH:13]=[CH:12][N:11]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]>O1CCCC1.[C].[Pd]>[CH2:1]([C:5]1[CH:23]=[CH:22][C:8]([CH2:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([CH2:20][CH3:21])[CH:18]=3)[CH:13]=[CH:12][N:11]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 59715735HCID 59715735, compound

Product 1

HCID 59715643HCID 59715643, compoundYield 10.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Palladium-carbon (10%, 5.0 mg) was added to a solution of the compound of Example B158 (2.0 mg) in tetrahydrofuran (2.0 ml), and the mixture was stirred at room temperature under nitrogen atmosphere (1 atm) for 1 hour. The catalyst was removed by filtration, and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give the title compound (0.21 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-2086269127d94cba9c2110c2f096df7c
Source dataset
uspto-grants-2011_08
Patent number
US07999090B2

Reaction notes

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