Methyl iodide → HCID 17851506, compound

HRID 1673099Notes

Reaction equation

HRID 1673099 reaction equation
[C:1](=[O:4])([O-])[O-].[K+].[K+].CI.[CH2:9]([C:13]1[CH:26]=[CH:25][C:16]([CH2:17][C:18]2[C:23](O)=[CH:22][CH:21]=[CH:20][N:19]=2)=[CH:15][CH:14]=1)[CH2:10][CH2:11][CH3:12].C(OCC)(=O)C>CC(C)=O>[CH2:9]([C:13]1[CH:26]=[CH:25][C:16]([CH2:17][C:18]2[C:23]([O:4][CH3:1])=[CH:22][CH:21]=[CH:20][N:19]=2)=[CH:15][CH:14]=1)[CH2:10][CH2:11][CH3:12]

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 59715655HCID 59715655, compound

Product 1

HCID 17851506HCID 17851506, compoundYield 7.2%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Potassium carbonate (33.0 mg, 0.239 mmol) and methyl iodide (14.9 μl, 0.239 mmol) were added to a solution of the compound of Example B230 (19.2 mg, 0.0796 mmol) in acetone (1 ml), and this reaction mixture was stirred at room temperature for 3 hours. After ethyl acetate was added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (1.47 mg).

Workup

  1. washthe reaction mixture was washed with saturated brine
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-41e52d76e77a45e8b36571d9d90dc59c
Source dataset
uspto-grants-2011_08
Patent number
US07999090B2

Reaction notes

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