反应详情

To a solution of EXAMPLE 17C (2.0 g) in tetrahydrofuran (10 mL) and water (5 mL) was added a solution of lithium hydroxide monohydrate (1 g) in water (5 mL). Methanol was added until a homogeneous solution formed. The solution was stirred at ambient temperature for 4 hours and concentrated to 5 mL. This was acidified with 2N hydrochloric acid to pH 2 and partitioned between ethyl acetate and water. The organic phase was washed with water, dried over magnesium sulfate, filtered and concentrated to give 1.5 g (79%) of the title compound. MS (DCI): m/z 213 (M+H)+.

1. customformed
2. concentrationconcentrated to 5 mL
3. custompartitioned between ethyl acetate and water
4. washThe organic phase was washed with water
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated