Hydrochloric Acid → HCID 59202348, compound

HRID 1673185Notes

Reaction equation

HRID 1673185 reaction equation
[OH-].[Na+].C([O:6][C:7](=[O:20])[C:8]1[CH:13]=[C:12]([F:14])[C:11]([O:15][CH2:16][C:17]#[CH:18])=[CH:10][C:9]=1[F:19])C#C.Cl>CO>[F:19][C:9]1[CH:10]=[C:11]([O:15][CH2:16][C:17]#[CH:18])[C:12]([F:14])=[CH:13][C:8]=1[C:7]([OH:20])=[O:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59202333HCID 59202333, compound

Product 1

HCID 59202348HCID 59202348, compoundYield 61.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a mixed solution of 20 ml of methanol and 20 ml of an aqueous 15% sodium hydroxide solution, 7.3 g of 2,5-difluoro-4-(2-propynyloxy)benzoic acid 2-propynyl ester was added, followed by stirring at 50° C. for 2 hours. The reaction mixture was added to hydrochloric acid and the obtained solid was collected by filtration. The solid was dried and washed with hexane, and 3.8 g of 2,5-difluoro-4-(2-propynyloxy)benzoic acid was obtained.

Workup

  1. filtrationthe obtained solid was collected by filtration
  2. customThe solid was dried
  3. washwashed with hexane

Sources & evidence

ORD record
ord-5c7b677c96574e7992971463a93ecc81
Source dataset
uspto-grants-2011_08
Patent number
US07999136B2

Reaction notes

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