Potassium Hydroxide → HCID 67020061, compound

HRID 1673216Notes

Reaction equation

HRID 1673216 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[C:12]2[O:14][C:15]([CH3:23])([CH3:22])[CH2:16][CH:17]([C:18]([O:20]C)=[O:19])[C:11]2=[CH:10][C:9]=1[C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=1.[OH-].[K+]>C1COCC1.CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[C:12]2[O:14][C:15]([CH3:23])([CH3:22])[CH2:16][CH:17]([C:18]([OH:20])=[O:19])[C:11]2=[CH:10][C:9]=1[C:24]1[CH:25]=[CH:26][C:27]([Cl:30])=[CH:28][CH:29]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 67019992HCID 67019992, compound

Product 1

HCID 67020061HCID 67020061, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
70 °C

Procedure

Product from Step A (66 mg, 0.14 mmol) was dissolved in THF (1 mL) and 10% KOH (1 mL) was added. The reaction was heated to 70° C. for 1 hr. The reaction was diluted with EtOAc and washed with 10% NaHSO4. The organic layer was separated, dried (Na2SO4), filtered and concentrated and used without any further purification

Workup

  1. washwashed with 10% NaHSO4
  2. customThe organic layer was separated
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customused without any further purification

Sources & evidence

ORD record
ord-7335f6b1f5564b859d1f30f37517659c
Source dataset
uspto-grants-2011_08
Patent number
US07999107B2

Reaction notes

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