Trifluoroacetic acid → HCID 67023921, compound

HRID 1673234Notes

Reaction equation

HRID 1673234 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]1[N:17]=[C:16]2[O:18][C:19]([CH3:31])([CH3:30])[CH2:20][CH:21]([NH:22]C(OC(C)(C)C)=O)[C:15]2=[CH:14][C:13]=1[C:32]1[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=1)[C:5]([O:7][CH3:8])=[O:6].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:22][CH:21]1[C:15]2[C:16](=[N:17][C:12]([C:11]3[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=3[Cl:1])=[C:13]([C:32]3[CH:33]=[CH:34][C:35]([Cl:38])=[CH:36][CH:37]=3)[CH:14]=2)[O:18][C:19]([CH3:31])([CH3:30])[CH2:20]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 24993725HCID 24993725, compound

Product 1

HCID 67023921HCID 67023921, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of Example 315 (200 mg, 0.36 mmol) in 5.0 mL of CH2Cl2 was added 500 μL of TFA. After stirring at rt for 16 h, the reaction mixture was concentrated. The amine TFA salt was taken onto next step without further purification.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe amine TFA salt was taken onto next step without further purification

Sources & evidence

ORD record
ord-15dc5dd305c24edc8d3394d0934a740a
Source dataset
uspto-grants-2011_08
Patent number
US07999107B2

Reaction notes

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