Hydrazine hydrate (1:1) → HCID 67020069, compound

HRID 1673236Notes

Reaction equation

HRID 1673236 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]1[N:17]=[C:16]2[O:18][C:19]([CH3:30])([CH3:29])[CH2:20][CH:21]([NH:22][C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25])[C:15]2=[CH:14][C:13]=1[C:31]1[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=1)[C:5](OC)=[O:6].O.[NH2:39][NH2:40]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]([NH:39][NH2:40])=[O:6])[CH:9]=[CH:10][C:11]=1[C:12]1[N:17]=[C:16]2[O:18][C:19]([CH3:30])([CH3:29])[CH2:20][CH:21]([NH:22][C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25])[C:15]2=[CH:14][C:13]=1[C:31]1[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67329693HCID 67329693, compound

Product 1

HCID 67020069HCID 67020069, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the product of Step B (22 mmol) and 2.0 mL of hydrazine hydrate in 10 mL of CH3OH was refluxed for 10 h. After cooling to rt, the reaction mixture was concentrated to give the product, which was taken into the next step without further purification.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customto give the product, which
  3. customwas taken into the next step without further purification

Sources & evidence

ORD record
ord-9c5d0b42ecbd41c283698378a1537c3f
Source dataset
uspto-grants-2011_08
Patent number
US07999107B2

Reaction notes

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