HCID 86622727, compound → HCID 67020004, compound

HRID 1673251Notes

Reaction equation

HRID 1673251 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C@H:29]([NH:30]C(=O)OC(C)(C)C)[CH2:28][C:27]([CH3:39])([CH3:38])[O:26][C:11]3=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][NH:23][CH:24]=3)=[CH:16][C:15]=2[Cl:25])=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C@H:29]([NH2:30])[CH2:28][C:27]([CH3:39])([CH3:38])[O:26][C:11]3=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][NH:23][CH:24]=3)=[CH:16][C:15]=2[Cl:25])=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 86622727HCID 86622727, compound

Product 1

HCID 67020004HCID 67020004, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of the product of Step A (364 mg, 0.64 mmol) in 10 mL of 20% TFA in CH2Cl2 was stirred at rt for 2 h. The reaction mixture was concentrated to give the product, which was used in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customto give the product, which
  3. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-d63484ccd2cf418998ce0e04e50901f1
Source dataset
uspto-grants-2011_08
Patent number
US07999107B2

Reaction notes

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