Methanol → HCID 57879481, compound

HRID 1673377Notes

Reaction equation

HRID 1673377 reaction equation
CO.[C:3]([NH:11][C:12]1[CH:20]=[C:19](/[CH:21]=[CH:22]/[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>[C].[Pd].C(OCC)(=O)C>[C:3]([NH:11][C:12]1[CH:20]=[C:19]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=[O:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 57879488HCID 57879488, compound

Product 1

HCID 57879481HCID 57879481, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

20 mg of 5% palladium-carbon was added to a mixed solution of 1 mL of methanol and 2 mL of ethyl acetate containing 0.10 g of 2-(benzamido)-4-((E)-2-phenylvinyl)benzoic acid and stirred under hydrogen atmosphere at room temperature for 5 hours. Insoluble were removed by filtration and the solvent was evaporated under reduced pressure. Hexane and diisopropyl ether were added to the obtained residue and a solid substance was separated by filtration to obtain 69 mg of 2-(benzamido)-4-phenethylbenzoic acid as white solid.

Workup

  1. customInsoluble were removed by filtration
  2. customthe solvent was evaporated under reduced pressure
  3. additionHexane and diisopropyl ether were added to the obtained residue
  4. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-dde5f2e799bd4aeab20709ac410d0bce
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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