Methanol → HCID 57879409, compound

HRID 1673391Notes

Reaction equation

HRID 1673391 reaction equation
CO.[C:3]([NH:11][C:12]1[CH:20]=[C:19]([C:21](=O)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>[C].[Pd].C(OCC)(=O)C>[C:3]([NH:11][C:12]1[CH:20]=[C:19]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=[O:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 57879578HCID 57879578, compound

Product 1

HCID 57879409HCID 57879409, compoundYield 76.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

30 mg of 5% palladium-carbon was added to a mixed solution of 1.5 mL of methanol and 2 mL of ethyl acetate containing the obtained 0.15 g of 2-(benzamido)-4-benzoylbenzoic acid and stirred under hydrogen atmosphere at room temperature for ten hours. Insoluble were removed by filtration and the solvent was evaporated under reduced pressure. Hexane was added to the obtained residue and a solid substance was separated by filtration to obtain 0.11 g of 2-(benzamido)-4-benzylbenzoic acid as white solid.

Workup

  1. customInsoluble were removed by filtration
  2. customthe solvent was evaporated under reduced pressure
  3. additionHexane was added to the obtained residue
  4. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-043f59d9216347c29e545e391e1fcce6
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

Loading…