Methanol → HCID 67342385, compound

HRID 1673407Notes

Reaction equation

HRID 1673407 reaction equation
[OH-:1].[Na+].[CH3:3][OH:4].[C:5]([NH:13][C:14]1[CH:23]=[C:22](COC2C=CC=CC=2)[CH:21]=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=O)(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>O1CCCC1>[C:5]([NH:13][CH:14]1[CH:23]=[CH:22][CH:21]=[CH:20][C:15]1([CH2:16][O:18][C:19]1[CH:10]=[CH:11][CH:6]=[CH:7][CH:8]=1)[C:3]([OH:4])=[O:1])(=[O:12])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 57879556HCID 57879556, compound

Product 1

HCID 67342385HCID 67342385, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.51 mL of 2.0 mol/b aqueous sodium hydroxide was added dropwise to a mixed solution of 3 mL of methanol and 3 mL of tetrahydrofuran containing 0.31 g of methyl 2-(benzamido)-4-(phenoxymethyl)benzoate while ice-cooled and stirred an room temperature for 5 hours and 30 minutes, the solvent was evaporated under reduced pressure and water was added and pH was adjusted to pH 4.0 with 1.0 mol/L hydrochloric acid. A solid substance was separated by filtration to obtain 0.21 g of 2-(benzamido)-1-(phenoxymethyl)benzoic acid as white solid.

Workup

  1. temperaturecooled
  2. customthe solvent was evaporated under reduced pressure and water
  3. additionwas added
  4. customA solid substance was separated by filtration

Sources & evidence

ORD record
ord-fcf2a9241e9648b2b13bec0f8509ee78
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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