Trifluoroacetic acid → HCID 57879342, compound

HRID 1673421Notes

Reaction equation

HRID 1673421 reaction equation
FC(F)(F)C(O)=O.[C:8]([NH:16][C:17]1[CH:29]=[C:28](/[CH:30]=[CH:31]/[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[OH:38])[CH:27]=[CH:26][C:18]=1[C:19]([O:21]C(C)(C)C)=[O:20])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:8]([NH:16][C:17]1[CH:29]=[C:28](/[CH:30]=[CH:31]/[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[OH:38])[CH:27]=[CH:26][C:18]=1[C:19]([OH:21])=[O:20])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67341418HCID 67341418, compound

Product 1

HCID 57879342HCID 57879342, compoundYield 81.6%

Procedure

3.0 mL of trifluoroacetic acid suspension containing 0.17 g of tert-butyl 2-(benzamido)-4-((E)-2-(2-hydroxyphenyl)vinyl)benzoate was stirred at room temperature for 30 minutes. The solvent was evaporated under reduced pressure, toluene was added, and the solvent was evaporated under reduced pressure. Hexane was added to the obtained residue and a solid substance was separated by filtration to obtain 0.12 g of 2-(benzamido)-4-((E)-2-(2-hydroxyphenyl)vinyl)benzoic acid as yellow solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, toluene
  2. additionwas added
  3. customthe solvent was evaporated under reduced pressure
  4. additionHexane was added to the obtained residue
  5. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-0cc13d4743594cd3807686b0a6ea2d28
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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