HCID 67342390, compound → HCID 57879361, compound

HRID 1673432Notes

Reaction equation

HRID 1673432 reaction equation
[F:1][C:2]1[CH:33]=[CH:32][C:5]([C:6]([NH:8][C:9]2[CH:21]=[C:20](/[CH:22]=[CH:23]/[C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=3)[CH:19]=[CH:18][C:10]=2[C:11]([O:13]C(C)(C)C)=[O:12])=[O:7])=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[CH:21]=[C:20](/[CH:22]=[CH:23]/[C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=3)[CH:19]=[CH:18][C:10]=2[C:11]([OH:13])=[O:12])=[O:7])=[CH:32][CH:33]=1

Participants

3

Reactant 1

HCID 67342390HCID 67342390, compound

Product 1

HCID 57879361HCID 57879361, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(4-fluorobenzamido)-4-((E)-2-(3-methoxyphenyl)vinyl)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 45 mg of 2-(4-fluorobenzamido)-4-((E)-2-(3-methoxyphenyl)vinyl)benzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-329e8a4afa804b04bbdbb23082b2abc0
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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