Trifluoroacetic acid → 2-(Benzamido)-4-(4-nitrophenyl)benzoic acid

HRID 1673457Notes

Reaction equation

HRID 1673457 reaction equation
FC(F)(F)C(O)=O.[C:8]([NH:16][C:17]1[CH:29]=[C:28]([C:30]2[CH:35]=[CH:34][C:33]([N+:36]([O-:38])=[O:37])=[CH:32][CH:31]=2)[CH:27]=[CH:26][C:18]=1[C:19]([O:21]C(C)(C)C)=[O:20])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:8]([NH:16][C:17]1[CH:29]=[C:28]([C:30]2[CH:35]=[CH:34][C:33]([N+:36]([O-:38])=[O:37])=[CH:32][CH:31]=2)[CH:27]=[CH:26][C:18]=1[C:19]([OH:21])=[O:20])(=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67342488Tert-butyl 2-(benzamido)-4-(4-nitrophenyl)benzoate

Product 1

HCID 578794682-(Benzamido)-4-(4-nitrophenyl)benzoic acidYield 43.3%

Procedure

3.0 mL of trifluoroacetic acid solution containing 40 mg of tert-butyl 2-(benzamido)-4-(4-nitrophenyl)benzoate was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure and ethyl acetate and methanol were added to she obtained residue and a solid substance was separated by filtration to obtain 15 mg of 2-(benzamido)-4-(4-nitrophenyl)benzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and ethyl acetate and methanol
  2. additionwere added to she
  3. customobtained residue
  4. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-24abcda32b684f88aa56d2d1895cf91e
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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