HCID 67343462, compound → HCID 57879500, compound

HRID 1673494Notes

Reaction equation

HRID 1673494 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[CH:11]=[CH:12]/[C:13]([NH:15][C:16]2[CH:28]=[C:27]([O:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:26]=[CH:25][C:17]=2[C:18]([O:20]C(C)(C)C)=[O:19])=[O:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[CH:11]=[CH:12]/[C:13]([NH:15][C:16]2[CH:28]=[C:27]([O:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:26]=[CH:25][C:17]=2[C:18]([OH:20])=[O:19])=[O:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 1

HCID 67343462HCID 67343462, compound

Product 1

HCID 57879500HCID 57879500, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-((E)-3-(3,4-dimethoxyphenyl)acrylamido)-4-phenoxybenzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure, and diisopropyl ether was add to the obtained residue, and a solid substance was separated by filtration to obtain 13 mg of (E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-4-phenoxybenzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and diisopropyl ether
  2. additionwas add to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-4791818de02c42bda241ce03b757affb
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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