HCID 67342373, compound → HCID 57879491, compound

HRID 1673505Notes

Reaction equation

HRID 1673505 reaction equation
C([O:4][C:5]1[CH:32]=[CH:31][CH:30]=[CH:29][C:6]=1[C:7]([NH:9][C:10]1[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:20]=[CH:19][C:11]=1[C:12]([O:14]C(C)(C)C)=[O:13])=[O:8])(=O)C>FC(F)(F)C(O)=O>[OH:4][C:5]1[CH:32]=[CH:31][CH:30]=[CH:29][C:6]=1[C:7]([NH:9][C:10]1[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:20]=[CH:19][C:11]=1[C:12]([OH:14])=[O:13])=[O:8]

Participants

3

Reactant 1

HCID 67342373HCID 67342373, compound

Product 1

HCID 57879491HCID 57879491, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2-acetoxybenzamido)-4-phenylbenzoate, and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and 0.50 mL of methanol, 0.50 mL of tetrahydrofuran and 6.1 mg of potassium carbonate were added to the obtained residue sequentially and stirred at room temperature for 2 hours. 10% citric acid aqueous solution was added to the reaction mixture and a solid substance was separated by filtration to obtain 8.2 mg of 2-(2-hydroxybenzamido)-4-phenylbenzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and 0.50 mL of methanol, 0.50 mL of tetrahydrofuran and 6.1 mg of potassium carbonate
  2. additionwere added to the obtained residue sequentially
  3. stirringstirred at room temperature for 2 hours
  4. addition10% citric acid aqueous solution was added to the reaction mixture
  5. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-aabb42b4d4c14cdcb37f7e1d0ed39ac4
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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