Methanol → HCID 57879299, compound

HRID 1673508Notes

Reaction equation

HRID 1673508 reaction equation
CO.[N+:3]([C:6]1[CH:30]=[CH:29][C:9]([C:10]([NH:12][C:13]2[CH:21]=[C:20]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:19]=[CH:18][C:14]=2[C:15]([OH:17])=[O:16])=[O:11])=[CH:8][CH:7]=1)([O-])=O>[C].[Pd].C(OCC)(=O)C>[NH2:3][C:6]1[CH:7]=[CH:8][C:9]([C:10]([NH:12][C:13]2[CH:21]=[C:20]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:19]=[CH:18][C:14]=2[C:15]([OH:17])=[O:16])=[O:11])=[CH:29][CH:30]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 57879392HCID 57879392, compound

Product 1

HCID 57879299HCID 57879299, compoundYield 108.6%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
40 °C

Procedure

3.0 mL of methanol, 2.0 mL of ethyl acetate and 4.0 mg of 5% palladium-carbon were added to 20 mg of 2-(4-nitrobenzamido)-4-phenoxybenzoic acid at room temperature and stirred under hydrogen atmosphere at 40° C. for 8 hours. Insoluble were removed by filtration, and the solvent was evaporated under reduced pressure to obtain 20 mg of 2-(4-aminobenzamido)-4-phenoxybenzoic acid as white solid.

Workup

  1. customInsoluble were removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-b8604bb665814ca88761d8a291876095
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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