Methanol → HCID 57879350, compound

HRID 1673509Notes

Reaction equation

HRID 1673509 reaction equation
CO.[N+:3]([C:6]1[CH:7]=[C:8]([CH:27]=[CH:28][CH:29]=1)[C:9]([NH:11][C:12]1[CH:20]=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])=[O:10])([O-])=O>[C].[Pd].C(OCC)(=O)C>[NH2:3][C:6]1[CH:7]=[C:8]([CH:27]=[CH:28][CH:29]=1)[C:9]([NH:11][C:12]1[CH:20]=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])=[O:10]

Participants

5

Reactant 2

HCID 887MethanolHCID 57879597HCID 57879597, compound

Product 1

HCID 57879350HCID 57879350, compoundYield 37.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
40 °C

Procedure

2.0 mL of methanol, 2.0 mL of ethyl acetate and 3.0 mg of 5% palladium-carbon were added to 15 mg of 2-(3-nitrobenzamido)-4-phenylbenzoic acid at room temperature and stirred under hydrogen atmosphere at 40° C. for 2 hours. Insoluble were removed by filtration, and the solvent was evaporated under reduced pressure to obtain 5.1 mg of 2-(3-aminobenzamido)-4-phenylbenzoic acid as white solid.

Workup

  1. customInsoluble were removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-f3eab499951947ada0efdc7d87783bb4
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

Loading…