Methanol → HCID 67343432, compound

HRID 1673514Notes

Reaction equation

HRID 1673514 reaction equation
CO.[C:3]([NH:11][C:12]1[CH:24]=[C:23]([NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[N+:32]([O-])=O)[CH:22]=[CH:21][C:13]=1[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>[C].[Pd].C(OCC)(=O)C>[NH2:32][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=1[NH:25][C:23]1[CH:22]=[CH:21][C:13]([C:14]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:15])=[C:12]([NH:11][C:3](=[O:10])[C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:24]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 67341565HCID 67341565, compound

Product 1

HCID 67343432HCID 67343432, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

10 mg of 5% palladium-carbon was added to a mixed solution of 4.0 mL of methanol and 8.0 mL of ethyl acetate containing 50 mg of tert-butyl 2-(benzamido)-4-(2-nitroanilino)benzoate and stirred under hydrogen atmosphere at room temperature for 1 hour and 30 minutes. After insoluble were removed by filtration, the solvent was evaporated under reduced pressure to obtain 46 mg of tert-butyl 4-(2-aminoanilino)-2-(benzamido)benzoate as pale yellow solid.

Workup

  1. customAfter insoluble were removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-e66b0d94baa2496480b8ce4a980a40ae
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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