Trifluoroacetic acid → HCID 57879326, compound

HRID 1673542Notes

Reaction equation

HRID 1673542 reaction equation
FC(F)(F)C(O)=O.[C:8]([C:10]1[CH:11]=[C:12]([CH:36]=[CH:37][CH:38]=1)[C:13]([NH:15][C:16]1[CH:28]=[C:27]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:26]=[CH:25][C:17]=1[C:18]([O:20]C(C)(C)C)=[O:19])=[O:14])#[N:9]>C(Cl)Cl>[C:8]([C:10]1[CH:11]=[C:12]([CH:36]=[CH:37][CH:38]=1)[C:13]([NH:15][C:16]1[CH:28]=[C:27]([O:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:26]=[CH:25][C:17]=1[C:18]([OH:20])=[O:19])=[O:14])#[N:9]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67344183HCID 67344183, compound

Product 1

HCID 57879326HCID 57879326, compoundYield 57.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.5 mL of trifluoroacetic acid was added to 0.5 mL of methylene chloride solution containing 10 mg of tert-butyl 2-(3-cyanobenzamido)-4-phenoxybenzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 5.0 mg of 2-(3-cyanobenzamido)-4-phenoxybenzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-114d2fe4f90e4aea9d8dcf727cd05ddf
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

Loading…