反应详情

温度

50 °C

1.0 mL of methanol and 0.5 mL of 2.0 mol/L aqueous sodium hydroxide were added to 1.0 mL of dioxane solution containing 20 mg of tert-butyl 4-phenyl-2-(4-(1H-pyrrol-1-yl)benzamido)benzoate at room temperature and stirred at 50° C. for 30 minutes. Ethyl acetate and 1.0 mol/L hydrochloric acid were added after the reaction mixture was cooled to room temperature. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure, Diisopropyl ether were added to toe obtained residue and a solid substance was separated by filtration to obtain 15 mg of 4-phenyl-2-(4-(1H-pyrrol-1-yl)benzamido)benzoic acid as white solid.

1. temperaturewas cooled to room temperature
2. customThe organic layer was separated
3. dry with materialdried over anhydrous magnesium sulfate
4. washafter washed with a saturated sodium chloride aqueous solution
5. customthe solvent was evaporated under reduced pressure, Diisopropyl ether
6. additionwere added
7. customto toe obtained residue
8. customa solid substance was separated by filtration