反应详情

温度

50 °C

1.0 mL of methanol and 0.5 mL of 2.0 mol/L aqueous sodium hydroxide were added to 1.0 mL of dioxane solution containing 20 mg of tert-butyl 4-phenoxy-2-(3-(1H-pyrrol-1-yl)benzamido)benzoate at room temperature and stirred at 50° C. for 30 minutes. After the reaction mixture was cooled to room temperature, ethyl acetate and 1.0 mol/L hydrochloric acid were added. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. Diisopropyl ether were added to the obtained residue and a solid substance was separated by filtration to obtain 7.6 mg of 4-phenoxy-2-(3-(1H-pyrrol-1-yl)benzamido)benzoic acid as white solid.

1. temperatureAfter the reaction mixture was cooled to room temperature
2. customThe organic layer was separated
3. dry with materialdried over anhydrous magnesium sulfate
4. washafter washed with a saturated sodium chloride aqueous solution
5. customthe solvent was evaporated under reduced pressure
6. additionDiisopropyl ether were added to the obtained residue
7. customa solid substance was separated by filtration