HCID 136026828, compound → HCID 135556648, compound

HRID 1673705Notes

Reaction equation

HRID 1673705 reaction equation
[CH2:1]([C:5]1[N:6]=[C:7](SC)[NH:8][C:9](=[O:26])[C:10]=1[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[C:19]([C:24]#[N:25])=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:14][CH:13]=1)[CH2:2][CH2:3][CH3:4]>[Ni].COCCOCCOC>[CH2:1]([C:5]1[N:6]=[CH:7][NH:8][C:9](=[O:26])[C:10]=1[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[C:19]([C:24]#[N:25])=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:14][CH:13]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 136026828HCID 136026828, compound

Product 1

HCID 135556648HCID 135556648, compoundYield 63%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8150DiglymeSolvent

Conditions

Temperature
160 °C

Procedure

A mixture of 4′-{[4-butyl-2-(methylthio)-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile (1.98 g), Raney-nickel (15 g) and 1-methoxy-2-(2-methoxyethoxy)ethane (25 mL) was stirred at 160° C. for 16 hr. The insoluble material was filtrated, and the filtrate was concentrated to give the title compound as colorless crystals (1.09 g, 63%).

Workup

  1. filtrationThe insoluble material was filtrated
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-fedafe090e924d4cb4f0dbc422162e6a
Source dataset
uspto-grants-2011_08
Patent number
US07998968B2

Reaction notes

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