Hydrochloric Acid → HCID 136146895, compound

HRID 1673955Notes

Reaction equation

HRID 1673955 reaction equation
[CH3:1][C:2]1[N:3]([CH2:31][C:32]2[CH:41]=[CH:40][CH:39]=[CH:38][C:33]=2[C:34]([O:36]C)=[O:35])[C:4](=[O:30])[C:5]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[NH:28][C:27](=[O:29])[O:26][N:25]=3)=[CH:14][CH:13]=2)=[C:6]([CH2:8][CH2:9][CH3:10])[N:7]=1.[OH-].[Na+].CO.Cl>O>[CH3:1][C:2]1[N:3]([CH2:31][C:32]2[CH:41]=[CH:40][CH:39]=[CH:38][C:33]=2[C:34]([OH:36])=[O:35])[C:4](=[O:30])[C:5]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[NH:28][C:27](=[O:29])[O:26][N:25]=3)=[CH:16][CH:17]=2)=[C:6]([CH2:8][CH2:9][CH3:10])[N:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 136026857HCID 136026857, compound

Product 1

HCID 136146895HCID 136146895, compoundYield 80.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of methyl 2-{[2-methyl-6-oxo-5-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-4-propylpyrimidin-1(6H)-yl]methyl}benzoate (0.28 g), 2 N aqueous sodium hydroxide solution (5 mL) and methanol (5 mL) was stirred at 50° C. for 3 hr. The reaction mixture was adjusted to pH 4 with water (20 mL) and 1 M hydrochloric acid, and the obtained crystallized product was collected by filtration to give the title compound as colorless crystals (0.22 g, 80%).

Workup

  1. customthe obtained crystallized product
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-98f3c209edd444cd8e2c2830e6c60bd8
Source dataset
uspto-grants-2011_08
Patent number
US07998968B2

Reaction notes

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