Ethylamine → Ethyl-(3-methyl-isoxazol-5-ylmethyl)-amine

HRID 1674657Notes

Reaction equation

HRID 1674657 reaction equation

Cl[CH2:2][C:3]1[O:7][N:6]=[C:5]([CH3:8])[CH:4]=1.[CH2:9]([NH2:11])[CH3:10]>C1COCC1>[CH2:9]([NH:11][CH2:2][C:3]1[O:7][N:6]=[C:5]([CH3:8])[CH:4]=1)[CH3:10]

Participants

4

Reactant 2

HCID 6341Ethylamine

HCID 71314965-(Chloromethyl)-3-methyl-1,2-oxazole

Product 1

HCID 57511318Ethyl-(3-methyl-isoxazol-5-ylmethyl)-amine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

prepared by reaction of 5-chloromethyl-3-methyl-isoxazole (Li W.-T. et al J. Med. Chem. 2003, 46, 9, 1706-1715) with 2M ethylamine in THF.

Sources & evidence

ORD record: ord-4e21e1ccb64440da9d1c86fdc177e539
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08003654B2

Reaction notes

Loading…