反应详情

温度

60 °C

18.6 g iron powder in 198 mL ethanol and 1.93 mL conc. aq. hydrochloric acid were stirred for 30 minutes at room temperature. 7.8 g (27.3 mmol) (RS)-S-(3-nitrophenyl)-N-(isopropylcarbamoyl)-S-methylsulfoximide in 20 mL methanol were added. The mixture was stirred at 60° C. for 2 hours and filtered over a bed of silica gel. The residue was washed with hot ethanol. The combined filtrates were evaporated. The crude residue was purified by column chromatography (silica gel, dichloromethane:dichloromethane/ethanol 1:1) to give 4.53 g (65% yield) of the title compound.

1. filtrationfiltered over a bed of silica gel
2. washThe residue was washed with hot ethanol
3. customThe combined filtrates were evaporated
4. customThe crude residue was purified by column chromatography (silica gel, dichloromethane:dichloromethane/ethanol 1:1)