3-Pyridinecarboxaldehyde → HCID 59149709, compound

HRID 1675121Notes

Reaction equation

HRID 1675121 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=O)[CH:2]=1.[CH3:9][C@H:10]1[CH2:15][NH:14][CH2:13][CH2:12][N:11]1[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][N:24]=2)[N:21]=1>>[CH3:9][C@H:10]1[CH2:15][N:14]([CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH2:13][CH2:12][N:11]1[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([F:27])([F:26])[F:28])=[N:23][N:24]=2)[N:21]=1

Participants

3

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 67341149HCID 67341149, compound

Product 1

HCID 59149709HCID 59149709, compoundYield 76%

Procedure

A mixture of pyridine-3-carboxaldehyde and 6-[(2S)-2-methylpiperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine (obtained as described in Example 358, preparation of starting materials) was allowed to react by General Synthetic Method 5, to give 6-[(2S)-2-methyl-4-(pyridin-3-ylmethyl)piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine in 76% yield.

Workup

  1. customto react by General Synthetic Method 5

Sources & evidence

ORD record
ord-838e4ba30f9e4bf1914895031fccde01
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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