反应详情

Methyl 4-(2-[dimethylamino]ethylamino)benzoate (1.00 g, 4.50 mmol) was dissolved in THF (30 ml). (2-Methylpropan-2-yl)oxycarbonyl tert-butyl carbonate (1.035 g, 4.72 mmol) was added and the solution was refluxed for 3 h. The solvent was then evaporated, the residue was dissolved in DCM, washed with sat. aq. ammonium chloride solution, dried over sodium sulphate, filtered and evaporated to give methyl 4-[2-dimethylaminoethyl-[tert-butoxycarbonyl]amino]benzoate (1.07 g, 74%) as a brown oil.

1. temperaturethe solution was refluxed for 3 h
2. customThe solvent was then evaporated
3. dissolutionthe residue was dissolved in DCM
4. washwashed with sat. aq. ammonium chloride solution
5. dry with materialdried over sodium sulphate
6. filtrationfiltered
7. customevaporated