Trifluoroacetic acid → HCID 67334725, compound

HRID 1675216Notes

Reaction equation

HRID 1675216 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10](=[O:38])[NH:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[CH:17][N:16]=[C:15]2[NH:22][C:23]1[CH:28]=[CH:27][C:26]([C:29](=[O:37])[NH:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:25][CH:24]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl.C(=O)(O)[O-].[Na+]>[NH2:7][CH2:8][CH2:9][C:10]([NH:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[CH:17][N:16]=[C:15]2[NH:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([NH:30][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)=[O:37])=[CH:25][CH:24]=1)=[O:38]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11562741HCID 11562741, compound

Product 1

HCID 67334725HCID 67334725, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 516892Sodium BicarbonateSolvent

Procedure

350 mg of the compound obtained in Example 80 dissolved in 7 ml of methylene chloride was reacted with 7 ml of trifluoroacetic acid at room temperature for 4 hours. The residue obtained from distillation of the reacted solution under a reduced pressure was stirred in 50 ml of saturated aqueous sodium bicarbonate for 30 mins, filtered under a reduced pressure, and dried to obtain the title compound (250 mg, 89%).

Workup

  1. customThe residue obtained from distillation of the reacted solution under a reduced pressure
  2. filtrationfiltered under a reduced pressure
  3. customdried

Sources & evidence

ORD record
ord-e570503dda934ea29b11f4fc79bc07d8
Source dataset
uspto-grants-2011_08
Patent number
US08003658B2

Reaction notes

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