Trifluoroacetic acid → HCID 67333649, compound

HRID 1675217Notes

Reaction equation

HRID 1675217 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10](=[O:35])[NH:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[CH:17][N:16]=[C:15]2[NH:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:25][CH:24]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl.C(=O)(O)[O-].[Na+]>[NH2:7][CH2:8][CH2:9][C:10]([NH:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[CH:17][N:16]=[C:15]2[NH:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:25][CH:24]=1)=[O:35]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86617509HCID 86617509, compound

Product 1

HCID 67333649HCID 67333649, compoundYield 105.1%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 516892Sodium BicarbonateSolvent

Procedure

480 mg of 2-[4-(biphenyl-4-ylamino)-quinazolin-6-ylcarbamoyl]-ethyl-carbamic acid t-butylester (prepared in accordance with the procedure of Example 80) dissolved in 10 ml of methylene chloride was reacted with 10 ml of trifluoroacetic acid at room temperature for 4 hours. The residue obtained from distillation of the reacted solution under a reduced pressure was stirred in 50 ml of saturated aqueous sodium bicarbonate for 30 mins, filtered under a reduced pressure, and dried to obtain the title compound (400 mg, 99%).

Workup

  1. customThe residue obtained from distillation of the reacted solution under a reduced pressure
  2. filtrationfiltered under a reduced pressure
  3. customdried

Sources & evidence

ORD record
ord-7dd5a3d95e32492cbad706034550a11a
Source dataset
uspto-grants-2011_08
Patent number
US08003658B2

Reaction notes

Loading…