Trifluoroacetic acid → HCID 67335089, compound

HRID 1675219Notes

Reaction equation

HRID 1675219 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][C:11](=[O:40])[NH:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[C:16]2[NH:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=2)=[C:26]([Cl:39])[CH:25]=1)(C)(C)C.FC(F)(F)C(O)=O.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[NH2:7][CH2:8][CH2:9][CH2:10][C:11]([NH:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[C:16]2[NH:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=2)=[C:26]([Cl:39])[CH:25]=1)=[O:40]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 11671466HCID 11671466, compound

Product 1

HCID 67335089HCID 67335089, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

0.76 g of the compound obtained in Example 86 dissolved in 22 ml of methylene chloride and 22 ml of trifluoroacetic acid was stirred at room temperature for 4 hours. The residue obtained from distillation of the reacted solution under a reduced pressure was stirred in 5 ml of methylene chloride while adding 50 ml of saturated aqueous sodium bicarbonate slowly, and filtered under a reduced pressure to obtain the title compound as solid (0.62 g, 99%).

Workup

  1. customThe residue obtained from distillation of the reacted solution under a reduced pressure
  2. filtrationfiltered under a reduced pressure

Sources & evidence

ORD record
ord-936258d96bc14059896790de121386f8
Source dataset
uspto-grants-2011_08
Patent number
US08003658B2

Reaction notes

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